C-CHEM² Project 3

Dr. Betsy Corwin and the CCHEM2 Field Team

Title: Metabolic, Microbiome, and Toxicant-Associated Interactions (MATRIX)

Purpose:

Characterize the metabolic pathways through which environmental exposures and the microbiom e contribute to preterm birth and infant neurodevelopment.

Goals:

  1. Identify maternal prenatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and preterm birth. 
  2. Identify maternal prenatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and infant neurodevelopment.
  3. Identify infant postnatal metabolic pathways and metabolite-microbiome correlations that link environmental exposures and infant neurodevelopment. 

Research Team:

  • Dr. Dean Jones, Project Lead
  • Dr. Betsy Corwin, Co-Project Lead -- Dr. Corwin studies the underlying biobehaviora l mechanisms that contribute to adverse maternal and infant outcomes, including chronic stress and inflammation, the role of the microbiome, and the metabolomics pathways involved.. This work is critical to our understanding-- and thus eliminating -- the health disparities in preterm birth and childhood health that plague African American families and our nation. .
  • Dr. Shuzhao Li, Project Co-Investigator